Search results for "primary [cosmic radiation]"
showing 10 items of 1110 documents
Circulating Tumor Cells (CTCs): A Unique Model of Cancer Metastases and Non-invasive Biomarkers of Therapeutic Response
2021
Late-stage cancer metastasis remains incurable in the clinic and is the major cause death in patients. Circulating tumor cells (CTCs) are thought to be metastatic precursors shed from the primary tumor or metastatic deposits and circulate in the blood. The molecular network regulating CTC survival, extravasation, and colonization in distant metastatic sites is poorly defined, largely due to challenges in isolating rare CTCs. Recent advances in CTC isolation and ex vivo culture techniques facilitates single-cell omics and the development of related animal models to study CTC-mediated metastatic progression. With these powerful tools, CTCs can potentially be used as non-invasive biomarkers pr…
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
The outcomes of national literacy programs on basic reading skills in familiar language among Zambian early graders
2016
In Zambia the Ministry of General Education implemented two national literacy programs in order to improve low levels of reading; the Primary Reading Program (PRP) implemented from 1999 to 2014 and the Primary Literacy Program (PLP) piloted in some schools in 2014 before being scaled up. This research examines the acquisition of basic reading skills among learners in familiar languages at the end of grade 2 in the two national literacy programs. I examined assessment results separately for each program and compared the two with each other. Outcomes were observed on the basis of the Early Grade Reading assessment test battery given to random samples of children (n=393) in 40 schools from 4 d…
Opetuskäytänteet ja niiden yhteys lukutaidon kehitykseen ensimmäisinä kouluvuosina
2018
Xin Tangin psykologian väitöskirja ”Teaching Practices in Early Primary School: Dimensions, Patterns and Consequences” tarkastettiin Jyväskylän yliopiston kasvatustieteiden ja psykologian tiedekunnassa 13. joulukuuta 2017. Vastaväittäjänä toimi apulaisprofessori Antje von Suchodoletz (New York University Abu Dhabi) ja kustoksena professori Marja-Kristiina Lerkkanen (Jyväskylän yliopisto). nonPeerReviewed
Identification of proprioceptive thalamocortical tracts in children: comparison of fMRI, MEG, and manual seeding of probabilistic tractography
2022
Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press. Studying white matter connections with tractography is a promising approach to understand the development of different brain processes, such as proprioception. An emerging method is to use functional brain imaging to select the cortical seed points for tractography, which is considered to improve the functional relevance and validity of the studied connections. However, it is unknown whether different functional seeding methods affect the spatial and microstructural properties of the given white matter connection. Here, we compared functional magnetic resonance imaging, magnetoencephalography, and manual seedin…
Predicting response to interpersonal counselling (IPC) from case formulation : a systematic comparison between recovered and unchanged depressive cas…
2019
We sought to explore how the process between the counsellor and patient for arriving at a case formulation may predict the outcome of manualized interpersonal counselling (IPC) for depression in primary care. Qualitative content analysis and applied conversation analysis (CA) were used to achieve depth in the understanding of case formulation process among five patients who recovered and five who were unchanged according to quantitative post-treatment change rates derived from Clinical Outcomes in Routine Evaluation– Outcome Measure (CORE-OM). Interaction in the case formulations for the recovered group was generally characterized by a joint construction effort between the counsellor and th…
The role of manikins in nursing students' learning: A systematic review and thematic metasynthesis
2021
Abstract Objectives To summarise and synthesise findings from qualitative primary research studies of nursing students' experiences from educational activities using manikins to gain a deeper understanding of the role these manikins play in the students' learning. Design and data sources A systematic review and thematic metasynthesis were conducted. Cinahl+, Ovid Medline, ERIC and Embase were searched systematically. Review methods Sandelowski and Barroso's framework guided the review process. A comprehensive search to identify qualitative studies of nursing students' experiences from learning with manikins was performed in January 2019 and updated in April 2020. Study selection was guided …
Development of Rat DC by in Vitro Culture of Bone Marrow Cells
1995
Dendritic cells (DC) represent a subpopulation of leukocytes of bone marrow (BM) origin, involved in crucial immunological reactions. DC play a fundamental role in the primary immune response by stimulating quiescent T cells. In this study we describe an in vitro culture system to raise DC from unfractionated bone marrow (BM) cells of LEWIS rats in the presence of low doses of mouse recombinant GM-CSF, that was successfully used in previous work to culture mouse DC1,2,3.
Diagnostische Aussagekraft von Sonographie und Computertomographie bei Lebermetastasen
1988
The diagnostic accuracy of sonography and computed tomography for detecting liver metastases was analysed in 526 patients with tumors and the findings were compared with those at laparotomy and at post mortem. The surgical protocols were analysed in respect of the primary tumour, the frequency of metastases and the number, localisation and size of metastases. A comparison of sonography and CT showed a higher sensitivity for CT (57.1%) compared with sonography (52.3%) although specificity was slightly higher for sonography. Liver metastases greater than 15 mm were detected by sonography (80.5%) and CT (92%), with much higher sensitivity. CT also proved superior, since the results depended le…
Recurrent intussusception of small bowel in a young patient due to metastases from cardiac undifferentiated pleomorphic sarcoma: A first ever case re…
2020
Highlights • Metastatic undifferentiated pleomorphic sarcoma (Malignant Fibrous Histiocytoma) is a rare entity in the visceral organs. • We report a case of a metastatic primary cardiac undifferentiated pleomorphic sarcoma which presented with a recurrent small bowel intussusception in a young man. • Laparotomy by a small midline incision performed on the same day identified an intussusception of a 15-cm section of small intestine caused by a 4-cm intraluminal metastasis from undifferentiated pleomorphic sarcoma. • Metastasis intussusception in the small intestine is a very rare condition and they are part of differential diagnosis in patient with a history of tumor who present with intussu…